Thoracic outlet syndrome--Dr. Richard Sanders

         In 1991, Dr. Sanders, authored the book "Thoracic Outlet Syndrome", which describes the causes, diagnosis, and treatment of TOS.  In 2015, Dr. Sanders, along with Dr. Stephen Annest, published another book, written in layman's terms, specifically for patients and non-physicians, entitled 'Thoracic Outlet Syndrome for Patients and Non-physicians'.  The book is available from Amazon.



         Thoracic Outlet Syndrome (TOS) is pain, numbness, tingling, and/or weakness in the arm and hand due to pressure against the nerves or blood vessels that supply the arm. It is due to tight muscles, ligaments, bands, or bony abnormalities in the thoracic outlet area of the body, which lies just behind the collarbone. Pressure on the nerves is the problem more than 90% of the time, but occasionally the artery or vein is involved.


Common Symptoms

     The most frequent complaints of nerve-type TOS (NTOS) are:

         *numbness and tingling in the fingers

         *pain in the neck, shoulder, and arm

         *headaches in the back of the head

         *weakness of the arm and dropping things from the hand

         *worsening of the symptoms when elevating the arm to do such things as comb or blow dry one's hair or drive a car

         *coldness and color changes in the hand.

The symptoms are often worse when using the arm for work or other activities or at night.  It is not necessary to have all of the symptoms to have neurogenic TOS (NTOS) or neurogenic PMS (NPMS).


Pectoralis minor syndrome

         In 2005 we became aware of a large number of patients who, in addition to these symptoms, also had pain in the chest wall, just below the collar bone, along with pain over the shoulder blade and in the arm pit. Until recently it was thought that these symptoms were due to TOS, but now it has been learned that they are due to a condition frequently accompanying TOS, namely pectoralis minor syndrome (PMS).



         TOS is most often produced by hyperextension neck injuries. Whiplash injuries in auto accidents and repetitive stress in the work place, are the two most common causes. Some of the occupations that we see causing TOS include working on assembly lines, keyboards, or 10-key pads, as well as filing or stocking shelves overhead. In some people, symptoms develop spontaneously, without an obvious cause. Pectoralis minor syndrome appears in more than half of the patients who have NTOS. It results from the same type of injuries that cause NTOS.  Pectoralis minor symptoms alone is seen in athletes who use their arms for activities such as swimming, throwing, volleyball, and weightlifting.


Cervical Rib

         An extra rib in the neck occurs in less than 1% of the population. People born with this rib, called a "cervical rib", are 10 times more likely to develop symptoms of TOS than other people. However, even in men and women with cervical ribs, it usually requires some type of neck injury to bring on the symptoms.



         Physical examination is most helpful. Common findings are tenderness over the scalene muscles, located about one inch to the side of the wind pipe. Pressure on this spot causes pain or tingling down the arm. Rotating or tilting the head to one side causes pain in the opposite shoulder or arm plus tingling in the hand Elevating the arms in the "stick-em-up" position reproduces the symptoms of pain, numbness, and tingling in the arm and hand. There is often reduced sensation to very light touch in the involved hand (this can only be detected in people with involvement on one side).

         In addition to these findings on physical examination of patients with NTOS, patients with neurogenic pectoralis minor syndrome (NPMS) have tenderness just below the collar bone about an inch or two inside the shoulder. Pressure on this spot often causes pain and tingling down the arm. Also, patients with NPMS often have tenderness in the armpit.


Diagnostic tests

         Diagnostic tests, such as EMG's or NCV's (nerve tests), may show non-specific abnormalities, but usually are normal in people with NTOS. However, recently a new nerve test was found which has been abnormal in the large majority of patients with NTOS and NPMS. This test can be considered a variation of EMG/NCV measurements. It is a determination of the medial antebrachial cutaneous nerve (abbreviated MAC). It is one of the few objective tests that can support the diagnosis.(Reported by Machanic, BI and Sanders, RJ in the Annals of Vascular Surgery, March, 2008.)

         Neck or chest x-rays may show a cervical rib. Loss of the pulse at the wrist when elevating the arm or when turning the neck to the side (Adson's sign), has been thought by some to be an important diagnostic sign. However, we find it unreliable because many normal people also lose their pulse in the same positions, and the majority of people with NTOS do not lose their pulse in this position. Shrinkage of hand muscles (atrophy) occurs in only 1% of people with NTOS, and these people will have nerve tests that show a typical pattern of ulnar nerve damage.

         Other diagnostic tests that are helpful are a scalene muscle block for NTOS and a pectoralis minor muscle block for the NPMS. These are simple office tests that involve a 15 second injection of lidocaine into the anterior scalene or pectoralis minor muscles. The tests give strong support to the correct diagnosis if within a minute or two of the injection there is good relief of symptoms and improvement in physical exam findings.

         Imaging by MRI is currently being investigated in a few centers for its value in diagnosing TOS. While subtle deviations from normal patterns are being recognized, their significance in guiding treatment has not yet been established. As of 2015, specific diagnostic criteria with this technique are still in the investigative stage.


Disease Process

         Microscopic examination of scalene muscles from the necks of people with TOS demonstrates scar tissue throughout the muscle. Presumably, this was caused by a neck injury stretching these muscle fibers. The tight muscles then press against the nerves to the arm (brachial plexus) producing the hand and arm symptoms. Neck pain and headaches in the back of the head may be caused by the tightness in these muscles but also can be the result of stretching muscles and ligaments along the cervical spine of the neck in cases of whiplash injury.



Physical Therapy

         Treatment begins with physical therapy and neck stretching exercises. Abdominal breathing, posture correction, and nerve glides, carried out on a daily basis, are a part of the therapy program. Gentle, slow movements and exercises are stressed. Methods like Feldenkrais have helped many people with NTOS. Modalities to avoid are those that emphasize strengthening exercises, such as therabands, heavy weights, and painful stretching. It is important to be examined and tested for other causes of these symptoms because other conditions can coexist with TOS, and these should be identified and treated separately. Some of these associated conditions include carpal tunnel syndrome, ulnar nerve entrapment at the elbow, shoulder tendinitis and impingement syndrome, fibromyalgia of the shoulder and neck muscles, and cervical disc disease. Surgery can be performed for NTOS and NPMS, but it should be regarded as a last resort.  Non-surgical forms of treatment should always be tried first.


Surgical Treatment

         Thoracic outlet surgery: This is designed to take pressure off the nerves to the arm and can be achieved by removing the muscles that surround the nerves (scalene muscles), by removing the first rib, or by doing both (removing muscles and first rib). Over the past 30 years we have employed each of these 3 operations in a quest for the safest and most effective procedure. All 3 procedures (transaxillary first rib resection, scalenectomy, and combined rib resection and scalenectomy) have limitations; there is no perfect operation.

         Recurrent symptoms of pain, numbness and tingling is most often the result of scar tissue formation during the healing period. This occurs regardless of which operation was performed. Between in 1997 and 2007, we tried 4 different different materials, similar to Saran wrap, to cover the nerves to the arm to reduce scar tissue adhering to the nerves after surgery. When we analyzed the results of each of these materials, we found that although they did reduce the amount of scar tissue making reoperations for recurrence easier, they did not significantly reduce the incidence of recurrent symptoms.  Regrettably, we have yet to find a material that will effectively reduce the incidence of failures following thoracic outlet surgery.


         Pectoralis minor surgery: In 2005 we became acquainted with the pectoralis minor syndrome, a condition that was described 60 years ago but which most of us had ignored (described above under "cause" and "diagnosis"). Each patient we now see for NTOS is also examined for this. We have been surprised to find that about 75% of the people who have NTOS also have complaints and positive physical exam findings ofNPMS.  If following a pectoralis minor muscle block there is significant improvement within a few minutes, we have been performing a very simple operation called pectoralis minor tenotomy. This operation can be performed as an outpatient under local anesthesia, but with an anesthesiologist in attendance so that patients are asleep for a short time but are awake within a few minutes of the end of the operation. The procedure carries minimal risks of injury.

         Between 2005 and 2007, 300 operations were performed that included the pectoralis minor muscle. Half of these were pectoralis minor operations alone; the other half combined pectoralis minor release with thoracic outlet operations.

Deciding who has thoracic outlet syndrome and who has pectoralis minor syndrome is determined by history, physical exam, and muscle blocks. Patients who are diagnosed with pectoralis minor syndrome alone are offered pectoralis minor release as the only operation. Those who are diagnosed with both conditions, and who note significant improvement following pectoralis minor block, are offered the simple operation of pectoralis minor tenotomy with the understanding that if they do not experience good relief of their symptoms they can return for the bigger operation of scalenectomy or first rib resection. Currently, about half of the patients receiving pectoralis minor tenotomies alone have returned for reoperations and received scalenectomies, some with first rib resection some without rib resection. The other half of the patients undergoing pectoralis minor surgery alone have reported good relief of symptoms and have not required additional surgery.  As of 2015, the number of patients receiving theseoperations is over 1000, but the results are about the same as described above.


Results of Treatment

         Most people with NTOS will improve with stretching and physical therapy. In our experience with over 5000 people with TOS, less than 30% had surgery.

The improvement rate with surgery varies with the cause of the TOS. Prior to 2005, auto injuries had a success rate of about 75% while repetitive stress at work has a success rate of 65-70%. Since adding pectoralis minor release to thoracic outlet operations the success rate has increased slightly in both groups.

         Pectoralis minor tenotomy as the only operation has two different success rates. Patients whose diagnosis is only pectoralis minor syndrome have a success rate of 90%.  Patients with both pectoralis minor syndrome and thoracic outlet syndrome, have a success rate for pectoralis minor tenotomy alone of only 35%. More than half of these patients have returned to have a thoracic outlet operation a later date. Following the second operation the success rate has been over 75%.


Recurrent thoracic outlet syndrome

         Recurrent symptoms after thoracic outlet operations, either rib resection or scalenectomy, are frequently due to pectoralis minor syndrome. In the past few  years, many patients who were reoperated upon for recurrence received the simple operation of pectoralis minor release while other patients required combined thoracic outlet reoperations plus pectoralis minor release. The success rate in both groups of patients has been over 60%.


For more Information

         In 2015, Dr. Sanders, along with Dr. Stephen Annest, published a more readable book for patients and non-physicians.  This book describes, in layman's terms, the 3 types of TOS and also the 3 types of the closely related Pectoralis Minor Syndrome (PMS).  The book is entitled 'THORACIC OUTLET SYNDROME FOR PATIENTS AND NON-PHYSICIANS.  The book is available through Amazon by typing, under books, either the name of the book or the author's name.


         Dr. Sanders is Board certified in both General Surgery and Vascular Surgery.  In addition to his books on TOS, he has authored several articles in medical journals and many chapters in surgical textbooks on the subject of TOS and PMS.

         If you would like to discuss your TOS problem, feel free to call Dr. Richard Sanders, M.D., in Denver at 303 388-6461, or call toll free, 1-888-756-6222.


Last updated in 2015